[2] In symptomatic patients, the pre-test probability should always be given weight in the interpretation of the CAC score as a filter or tool to indicate the best method to facilitate the diagnosis.
[2] In patients with diabetes, the CAC score helps identify the individuals most at risk, who could benefit from screening for silent ischemia and from more aggressive clinical treatment.
[5] There is potential to measure CAC on chest radiographs taken for other indications, possibly allowing some primary screening for coronary artery disease without adding to radiation exposure and with minimal marginal cost.
[7] The original work, published in 1990,[8] was based on electron beam computed tomography (also known as ultrafast CT or EBCT).
For example, a "speck" of coronary calcification in the left anterior descending artery measures 4 square millimeters and has a peak density of 270 HU.
[11] Each individual calcified lesion is characterized and measured using parameters including the width, length, density, and distance from the entrance of the major coronary arteries.
[10] On average, a single scan will expose a patient to about 2.3 millisieverts of radiation, equivalent to 23 chest x-rays (front and side views).