It is home to the five-time national champion Boston University Terriers men's ice hockey team.

The BU basketball team played games at the arena until 2015, before moving back to Case Gym.

[10] BU's men's ice hockey team had previously played at Walter Brown Arena for 33 years.

Walter Brown was known for being extremely loud during high attendance games due to its low ceiling, creating a home advantage.

Coach Jack Parker consulted with architects when designing the rink to ensure that the volume level would remain high.

[11] The arena is named after Harry Agganis, a two-sport football and baseball athlete for BU and a player for the Boston Red Sox.

The school made the decision before the 2015–2016 season to move all home games back to Case Gym due to poor attendance at Agganis.

[19] Agganis Arena hosted the first rounds of the 2007 America East men's basketball tournament and the finals in 2011.

[23] In January 2018, the arena hosted the playoff stage for the ELEAGUE Major tournament for Counter-Strike: Global Offensive.