Facing constant frustration every day from pushy superiors and co-workers, Retsuko lets out her emotions by going to a karaoke bar every night and singing death metal.

[5][6] After five years of working the daily grind, Retsuko's misery causes her to undergo a series of events that puts her job in jeopardy, forcing her to shift her relationships with her co-workers and ends up changing her life in unexpected ways.

[14] In July 2020, a mobile game, Aggretsuko: The Short Timer Strikes Back, was released by Hive for Android and iOS devices.

For every ten levels completed, the user can download and see the episodes of the original one minute length TV Anime shorts.

[23] The first season of the Netflix series holds a 100% on Rotten Tomatoes based on 25 reviews, with the sites critic consensus reading, "Uniquely bleak for a Sanrio property, Aggretsuko balances biting corporate satire with adorable characters and absurdist comedy to create a surprising, insightful addition to the world of animation.

[25] IndieWire gave the season a B+, and noted the distinctly Japanese stylistic elements of the animation that made it stand out from American productions.

Club praised Aggretsuko for dealing with mature themes like misogyny and workplace anxiety, but criticized the season's romantic subplot, calling it "aggressively lousy".

[34] Jacob Oller from The Spool wrote that the season was "all sorts of fun" and that "Aggretsuko continues to resonate, echoing through the skulls of rage-filled office workers everywhere," while praising the relatability of the anti-capitalist attitude possessed by Retsuko.

[35] IGN writer Britteny Vincent wrote that Season 4 "brings the absurdity and laughs to the reality of a manipulative workplace" but criticized the dynamic between Retsuko and Haida, referring to them as two of the show's "most frustrating characters", for diluting the overall experience.

[36] Petrena Radulovic of Polygon wrote that the fourth season "should inspire everyone to unionize their workplace", and praised the show's ability to balance "wild scenarios with more specific and relatable situations.