[8][9][10][11] On the planet Mars, there existed a race of anthropomorphic mice who enjoyed motorsports and had a very similar culture and society to that of human beings.

Three survivors, Throttle, Modo and Vinnie, manage to escape on a spaceship, but are shot down by a Plutarkian warship and crash-land on Earth in the city of Chicago.

There they meet a charming female mechanic named Charlene "Charley" Davidson and discover that the Plutarkians have come to Earth to steal its natural resources.

The Biker Mice investigate the crumbling ghetto of the windy city and soon discover that Chicago's leading industrialist, Lawrence Limburger, is actually a Plutarkian who disguises himself as a human, plotting to ransack Earth's resources to send to his own dying planet.

Limburger enlists two henchmen, mad scientist Dr. Karbunkle and the idiotic Greasepit, to help him steal Earth's natural resources and send them to Plutark with the help of some supervillains that they transport from another location in the galaxy.

The most frequent sign of victory is destroying Limburger's tall tower, forcing him to constantly spend money and time to rebuild it by the next episode.

GP retained Pangea as developers of the toy line, working in tandem with creator and executive producer, Rick Ungar.

The team of Ungar, G7, and Pangea collaborated in order to maintain consistency between the intellectual property and the execution of the primary toy range, as the GP licensing monies were utilized to set in motion the series development.

[18][19] In 2006, another Biker Mice from Mars video game was released based on the 2006 revival in Finland, Australia and the United Kingdom for the Nintendo DS and PlayStation 2 platforms.