Agkistro or alternatively Agistro (Greek: Άγκιστρο, pronounced [ˈaɟistɾo]), is a village in the Serres regional unit, Greece.

[4][5] The gold and silver mines found in the mountain of Agkistro, south of the modern village, are believed to have provided valuable material to the armies of Ancient Macedon and especially to the campaign of Alexander the Great, during the 4th century BC,[6] although in archaeological bibliography the specific location has not been identified as one of the ancient mining sites.

[6] South of the village lies Rupel Fort, which was part of the Greek line of defense that withstood the German invasion in the spring of 1941, during World War II.

[16] Despite the general financial crisis in Greece, there is no local unemployment, with over thirty businesses catering to the tourist industry.

[19] In Fort Roupel, which is today a war museum, memorial celebrations are held each year on the 6th of April.