She made her US debut in early 1858 as Agnes Land, performing with her sister Belle at Maguire's Opera House, San Francisco, attracting attention and gaining recognition and managing a season of the Metropolitan theatre in Detroit.

"For painstaking attention to detail, nicety of intonation, and powerful expression, Agnes Booth is in the front rank of leading ladies.

[8] In 1874, she and Junius made a praise-worthy trip to the far west playing San Francisco's California Theater and Piper's Opera House in Virginia City.

[9] In 1878 she played Madeleine Renaud in the Union Square Theatre's production of A Celebrated Case, the program noting that she had "kindly undertaken this part in order to strengthen the cast."

Booth gained fame for her role in the melodrama The Sporting Duchess (The Derby Winner by Cecil Raleigh) along with fellow actress and New Rochelle neighbor Cora Tanner.