On 31 March 1425 at Settimo Pavese, at approximately age 14, Agnese gave birth to Filippo's daughter, whom they named Bianca Maria.
The extravagant festivities, which lasted for days, offered a sumptuous banquet, a series of tournaments, a palio, painted carts featuring allegorical scenes, and an oversized cake that reproduced the Torrazzo, Cremona's most prominent tower.
A revolt broke out in Milan on 24 February 1450, due to a famine in the city which resulted in rampant starvation and brought about much suffering to the populace.
One month later on 25 March, after the disputed succession to the duchy was decided in their favour consequent to a meeting of nobles and leading citizens, Francesco Sforza and Bianca Maria made their triumphal entry into the city as the Duke and Duchess of Milan.
Extant diplomatic papers record that Agnese was a conspicuous participant in court functions,[3] until her death on 13 December 1465 at the age of fifty-four years.
The role of Agnese was played by Anna del Serre when the opera was first performed at Teatro La Fenice in Venice on 16 March 1833.