While he was Doge, the imposing Clock Tower in the Piazza San Marco with its archway through which the street known as the Merceria leads to the Rialto, was designed and completed.

His relationships with the Ottoman sultan Bayezid II were initially amicable, but they became increasingly strained starting from 1492, eventually leading to open war in 1499.

Despite his personal opposition, in February 1499 Venice signed the Treaty of Blois, a military alliance with Louis XII of France against their long-standing rival, the Duchy of Milan.

[3] Barbarigo believed it to be a distraction from the Ottoman threat; a peace treaty was signed in 1503, which left Venice holding only Nafplion, Patras and Monemvasia in Morea.

Part of it, a relief showing the Resurrection of Christ, is in the Scuola di San Giovanni Evangelista, attributed to the workshop of Antonio Rizzo.