Subsequently, between 1793 and 1808, she made six voyages as a slave ship, alternating between the triangular trade in enslaved people, and sailing as a regular West Indiaman.

[1] 1st voyage transporting enslaved people (1793–1794): War with France had commenced a few months earlier leading Captain Thomas Johnson to acquire a letter of marque on 7 June 1793.

[6][a] 2nd voyage transporting enslaved people (1794–1795): Captain Johnston sailed from Liverpool on 31 July 1794.

Sir John Borlase Warren's squadron recaptured Agreeable on 15 March and sent her into Falmouth, where she arrived on the 23rd.

After about 20 minutes the Spaniard veered off, but proceeded to follow Barton all night at a distance of half a mile.

The engagement lasted one hour and forty minutes before the Spaniard disengaged, having suffered extensive damage to her sails and rigging.

3rd voyage transporting enslaved people (1797–1798): Captain James Hird acquired a letter of marque on 28 October.

She left Africa on 18 March and arrived at St Vincent on 2 May, having stopped at Barbados on the way.

Victor Hugues put 210 men onboard her, armed her with eighteen 12-pounder guns, and sent her to cruize off Barbados.

[17] A Royal Navy sloop-of-war captured Agreeable, "of Guadaloupe (late of Liverpool)", and carried her into Tortola.

4th voyage transporting enslaved people (1799–1800): Captain Walter Stott acquired a letter of marque on 2 July 1799.

[20] 5th voyage transporting enslaved people (1802–1803): Although the change of masters did not appear in LR, on 6 July 1802 Captain George Hewitt sailed from Liverpool.

She sailed St Kitts on 17 August and arrived in Liverpool on 27 September with William Good as master.

[21] 6th voyage transporting enslaved people (1807–1808): Captain James Young sailed from Liverpool on 1 January 1807.

She arrived at Trinidad on 21 November with 164 captives, with the principal place of landing being Zion Hill.

Agreeable repelled the privateer after a severe engagement and arrived at Antigua 83 days after leaving Liverpool.

There was a report, that proved false, that an American privateer had captured Agreeable off the coast of Africa.

There she had run aground on the Chico Bank in the River Plate and vessels had to be sent out from Buenos Aires to take off her cargo.

[25] Agreeable, Garnock, master, arrived in Buenos Aires in late December 1813 having suffered considerable damage from having run aground.

[26] Agreeable was condemned in Buenos Aires after having run aground in the River Plate.

On 16 March 1816 Agreeable arrived in Rio de Janeiro with the cargo from Tiger, Smith, master, of Leith, which had wrecked on Cape St Rock.