According to tradition, Agricola ("farmer") was the son of Saint Magnus, also a bishop of the city.

He was a well-known preacher, and famous for his charity and defense of the poor and sick against civil authorities.

[2] At the end of the 11th century, Bishop Arbert of Avignon made a donation that referred to the abbey of Saint-Agricol; the church of Saint-Agricol (Saint Agricola) that seems to have been built in the 12th century was made collegial in 1321 by Pope John XXII, one of the Avignon-based popes, who equipped it with a statute and income.

In 1647, he was declared patron saint of the city of Avignon by Archbishop César Argelli.

Devotees prayed to the saint whose name signifies "cultivator of fields" for good weather, fine harvests, and rain during times of drought.