She is best known for her portrayal of an innocent child who lost her money on the way to buy goldfish from the market, in the film The White Balloon (1995) directed by Jafar Panahi.
In 1995 Mohammadkhani made her acting debut in the award-winning film The White Balloon, playing the child protagonist Razieh, a film by Jafar Panahi at the age of seven years.
Mohammadkhani received her master's degree in clinical psychology from Alzahra University.
From 2015 to 2017 she was a visiting scholar at Rutgers University in the laboratory of Dr. Gary Aston-Jones.
Currently, she is a post-doctoral fellow in the laboratory of Dr. Stephanie Borgland at the Hotchkiss Brain Institute of the University of Calgary.