After graduating from high school, Turturro earned a Bachelor of Arts degree in theatre from the State University of New York at New Paltz.

In 2009, Turturro appeared in "Bite Me", a sixth-season episode of the CBS series Medium, playing the evil Bobbi Catalano.

In 2012, Turturro appeared in "Day of the Iguana", an episode of Nurse Jackie, which reunited her with her Sopranos co-star Edie Falco.

Since 2013, she has guest-starred in several episodes of Law & Order: Special Victims Unit as Judge Felicia Catano.

In 2017, Turturro appeared in "Il Mostro" in the second season of Criminal Minds: Beyond Borders.