Air Guyane SP was a French Guianan regional airline with its head office on the grounds of Cayenne-Rochambeau Airport in Matoury.

[3] On June 1, 2002, Air Guyane Express began operations after taking over the former airline Air Guyane operations.

[citation needed] It also operates in the French Antilles with 2 ATR 42 aircraft on routes between Fort-de-France, Pointe-à-Pitre, Saint Martin and Sainte Lucie under the brand Air Antilles Express.

The airline was placed into liquidation by the Mixed Commercial Court of Pointe-à-Pitre on August 2, 2023,[4] and it was folded on October 1 of the same year.

[1] By April 2023, Air Guyane Express operated scheduled passenger flights to the following destinations:[5] Air Guyane consisted of the following aircraft (as of April 2023).