[2] The airline operates scheduled services between the islands of Saint-Pierre and Miquelon-Langlade as well as to Canada.

The airline was founded in 1964 and originally flew in cooperation with Eastern Provincial Airways.

The operator's first aircraft was a Piper Aztec, which was put into service flying to Sydney, Nova Scotia.

Services commenced in June with a cooperation with Eastern Provincial Airways, allowing codesharing with EPA's Douglas DC-3 between Saint-Pierre and Sydney.

Air Saint-Pierre thereafter started conducting charter flights with a Piper Aztec.

Miquelon Airport opened in 1979, allowing Air Saint-Pierre to commence an inter-island service to the larger island of Miquelon-Langlade.

[8] Air Saint-Pierre flies transatlantic to Paris, once a week during the peak season, are operated by ASL using a Boeing 737-700.