[13] Aisha Buhari is a member of the United Kingdom Vocational Training and Charitable Trust and the International Health and Beauty Council.

In July 2014, Aisha advised Goodluck Ebele Jonathan to resign from office as president of Nigeria, following a suicide bombing and an alleged assassination attempt on her husband by the Boko Haram terrorist group.

Aisha raised concerns on child sexual abuse in Nigeria, sex trafficking and the need for legislation against early marriage.

"[23] In April 2021, she attended the book of "Aisha Buhari – Being Different", written by Hajo Sani, the Senior Special Adviser to the President on Women Affairs and Administration.

[26] "Future Assured" is an initiative founded by Aisha Buhari to continue her advocacy work for the health and well-being of women and children through community mobilization and goodhealth promotion.

Aisha was prompted by the need to improve the current poor health outcomes of women, children and other vulnerable groups of the Nigerian population.

She affirmed her commitment to this work at a stakeholders meeting held at the presidential villa and a public launch[27] of Future Assured programs at the sidelines of the United Nations General Assembly in New York on 29 September 2015.

[30] Aisha Buhari surprised Nigerians when she made it known that her role as the wife of the president of Nigeria will be limited to whatever is constitutionally recognized, and she promised not to overstep.

[36][37] In the early months of 2022, Nigerian university student Aminu Adamu Mohammed posted on the social media platform Twitter, mentioning Aisha in a tweet in what can be interpreted as a defamatory manner.

But roughly translated into English from a court transcription of the Hausa phrase Aminu tweeted, "Mama is feeding fat on poor people's money.