[1] After the Sammarinese skeleton law on higher education had been passed the academy was officially founded on 13 September 1985,[2] in the presence of the Captains-Regent.
[3][4] The AIS was founded on an initiative of scientists from various countries, such as Helmar Frank, Humphrey Tonkin, and Reinhard Selten.
Conventions and summer schools were held in Bulgaria, Korea, the Czech Republic, Germany, France, Italy, Poland, Romania, Russia, Slovakia and Sweden.
Some 300 scientists contributed to the AIS as members of the "International Scientific College" (Internacia Scienca Kolegio, ISK).
A notable rector was Fabrizio Angelo Pennacchietti, an Italian orientalist who graduated from La Sapienza.