Although he had good grades in high school, he was missing a course to be able to accept the scholarship from Purdue University, so he enrolled at Coffeyville Community College for one year.

He received second-team NJCAA All-American, All-Jayhawk and Mission Conference Defensive Player of the Year honors.

He was named first-team All-Big Ten Conference as a senior and second-team All-Conference as a sophomore and junior.

He was tied with Jeff Zgonina for second on Purdue's career-record list with 29 sacks, topped only by Rosevelt Colvin with 33.

[2] As a rookie, he had 3 starts at strongside linebacker because of injury to Eric Westmoreland and also saw considerable time as a rush end on passing downs.

In 2003, he was named a starter at outside linebacker, while posting 150 tackles (second on the team), one sack, 4 passes defensed, 2 interceptions and 3 fumble recoveries.

Coincidentally, as a child growing up in Irving, Ayodele was a ball boy for the Cowboys in high school.

On April 25, Ayodele was traded along with tight end Anthony Fasano to the Miami Dolphins in exchange for a fourth-round pick (#100-Tyvon Branch) in the 2008 NFL draft.

[4] In 2008, he reunited with former Cowboys head coach Bill Parcells, who was the team's Executive Vice President of Football Operations with the Miami Dolphins.

He started in the AFC wild card game against the Baltimore Ravens, tying for a team-high 6 tackles and having one pass defensed.

[7] On September 10, 2010, the Buffalo Bills signed Ayodele to take the spot of LB Kawika Mitchell after the team placed him on the injured reserve list.