Akuammine (vincamajoridine[2]) is an indole alkaloid.

It is the most abundant alkaloid found in the seeds from the tree Picralima nitida,[3] commonly known as akuamma, comprising 0.56% of the dried powder.

[2] Akuammine is structurally related to yohimbine, mitragynine and more distantly Voacangine, all of which are alkaloid plant products with pharmacological properties.

Akuammine has antimalarial activity,[3] and may be the primary constituent of P. nitida seeds responsible for this activity.

[4] Akuammine is an opioid agonist with low affinity, selective for the mu-opioid receptor, when tested in vitro.