Akwasi Opong-Fosu (born 1 February 1958) is a Ghanaian politician.

He was appointed Minister for Local Government and Rural Development by President John Dramani Mahama in March 2013,[2] and succeeded by Julius Debrah in that title in May 2014.

He entered the University of London and obtained his master's degree in Public Policy and Management in 2002.

[4] Fosu is a member of the National Democratic Congress (NDC).

In 2012, he contested for the Amenfi East seat on the ticket of the NDC sixth parliament of the fourth republic and won.