Owusu-Ansah played college football for the IUP Crimson Hawks of NCAA Division II.
[3] Prior to his senior season in 2009 he was ranked as the ninth-best cornerback in the nation, and the only non-Division I player in the top 18.
[3] He was selected for the 2010 East-West Shrine Game, but could not participate due to a shoulder injury suffered during his senior season.
Just before the surgery, Owusu-Ansah participated in the Pro Day workout at Ohio State University, where he recorded the fastest 40-yard dash time.
Although he was considered to be inexperienced coming from a small school background and was also recovering from a shoulder injury he suffered as a senior, Owusu-Ansah was selected by the Dallas Cowboys in the fourth round (126th overall) of the 2010 NFL draft,[6] because of his athletic measurables.
[7] In the process, the team passed on other defensive backs like Kam Chancellor, Kendrick Lewis, Nolan Carroll, Sherrick McManis and Reshad Jones.
[8] As a rookie, he was moved between the safety and cornerback position, earning the job as the team's primary kickoff returner.
He was promoted to the active roster on December 6, after the Jaguars released tight end Fendi Onobun.
[16] On December 23, 2014, he was assigned to the Los Angeles KISS of the Arena Football League but refused to report.
[18] He posted 30 tackles and was a part of the Grey Cup championship team, that had a 27-24 win against the Calgary Stampeders on November 26.