[12] After the 1948 Arab–Israeli War and occupation of the Gaza Strip by Egypt, the American Baptist Foreign Mission Society operated the hospital.

In 1996, in response to a series of bus bombings, Israel shut Gaza’s borders, which halted commercial and agricultural goods transport.

[7] According to the Anglican Communion News Service, at 7:30 p.m. EEST on 14 October 2023, the hospital's Diagnostic Cancer Treatment Centre was damaged by Israeli rockets, causing four hospital staff members to be injured and severely damaging two of its upper floors, with the mammography and ultrasound departments affected the most.

[15] Three days later, on the evening of 17 October, an explosion occurred in the courtyard which was housing thousands of displaced people as a result of the war.

[16] An independent analysis by Human Rights Watch concluded that the cause of the explosion was likely a misfired Palestinian rocket.

[7] In July 2024, the hospital was forcibly closed and evacuated, leading to condemnation by the Archbishop of Canterbury, who stated, "In the face of intense Israeli bombardment, this closure puts injured and sick people in even greater danger".