In 2014, several shells hit the hospital's intensive care unit in an IDF bombing campaign that was targeting anti-tank missiles in the area.

[6][7] IDF airstrikes in Deir al-Balah and around the hospital resulted in hundreds of deaths and injuries.

"[11][12] Following a visit to the hospital, the World Health Organization found 70% of staff and many patients had fled.

[21] In August 2024, at least four Palestinians including a woman were killed and 18 were injured in an Israeli bombing of tents used by displaced people in the courtyard of the hospital.

[28] On the night of Sunday, October 13, 2024, Israeli warplanes targeted Shuhada al-Aqsa Hospital in the heart of Gaza, igniting a massive fire.

The White House stated that the images and videos depicting Palestinian refugees burning alive as a result of this Israeli attack are profoundly disturbing and horrifying.

Shaban al-Dalou[a] was a 19-year-old software engineering student and Palestinian refugee living in the heart of Gaza.

He shared images depicting the plight of Palestinian refugees and released videos showcasing the wounded at Shuhada al-Aqsa Hospital, highlighting their urgent need for blood donations.