Al-Duhail SC whose team has regularly taken part in Asian Football Confederation (AFC) competitions.

Their first participation in the AFC Champions League was in 2012, and their first match was against Al-Ahli of Saudi Arabia and ended with victory despite that Al-Duhail was eliminated from the group stage.

The following year Al-Duhail achieved a historic participation as it reached the quarter-finals and was eliminated against Guangzhou Evergrande which won the title afterwards.

[1][2] Al-Duhail SC as the holder of the 2019–20 Qatar Stars League title, was included in participating in the FIFA Club World Cup and the first match was expected against Auckland City but the latter withdrew due to the COVID-19 pandemic and related quarantine measures required by the New Zealand authorities, and in the second round it was defeated against Al Ahly, so that Al-Duhail SC was finished fifth place by defeating Asian champion Ulsan Hyundai.

On April 21, 2021, Michael Olunga scored Al-Duhail's first hat-trick in the AFC Champions League against Esteghlal in a victory 4–3.