Nearby localities include Kahil to the southwest, al-Jiza to the south, al-Sahwah to the southeast, 'Ara to the east, Umm Walad to the northeast, al-Karak to the north, al-Ghariyah al-Sharqiyah to the northwest and Saida to the west.

They paid a fixed tax-rate of 40% on agricultural products, including wheat, barley, summer crops, goats and/or beehives; a total of 6,300 akçe.

[5] In 1838, during late Ottoman rule, al-Musayfirah was found to be located south of al-Shaykh Maskin, and was classified as a khirba (abandoned village) by biblical scholar Eli Smith.

[6][7] Throughout this era and during French rule (1918–46), 16 villages in the region were controlled by the al-Zu'bi clan which also provided many of the religious sheikhs of the Sufi order, Qadiriyyah, founded by Abd al-Qadir al-Jilani.

[8] In September 1910 al-Musayfirah served as a destination of Ottoman troops before launching a punitive expedition against Druze rebels in Jabal Hauran, just to the east.

[9] During the Great Syrian Revolt against the French Mandate, the Muslim sheikh (chieftain) of al-Musayfirah, Muhammad al-Zu'bi, and his horsemen joined the Druze rebels of Sultan Pasha al-Atrash in the Jabal in August 1925.

[3] On 29 July 2011, during the ongoing Syrian civil war which began in March 2011, an anti-government demonstration in al-Musayfirah was dispersed by security forces who opened fire on protesters, killing a civilian.

[14] On 11 September, Reuters reported that 40 people from al-Musayfirah were forcibly detained by security forces, among dozens of others from nearby towns, namely al-Jiza and Busra al-Harir.