Hosted by Al Franken, it featured commentary and interviews arguing for liberal positions on the issues of the day, and comically poking fun at the George W. Bush Administration.

Between January 3, 2006, and February 14, 2007, the show was recorded and broadcast from the 28th floor of the historic Foshay Tower in downtown Minneapolis, Minnesota.

The final show was broadcast on February 14, 2007, the day Franken announced his candidacy for the United States Senate election of 2008.

Lanpher left the show to write Leap Days, a memoir about her experiences moving to New York City.

[4][needs update] At the end of his final show, Franken announced his intention to run for the United States Senate from Minnesota.

O'Reilly is widely thought to have instigated Fox News Channel's lawsuit against Franken for using their trademarked phrase "fair and balanced",[5] which was thrown out of court in summary judgment, but ended up giving publicity to Franken and his book Lies and the Lying Liars Who Tell Them.

The show's regular guests included respected progressive issues and current events analysts: Jonathan Alter, David Brock, Joe Conason, John Dickerson, James Fallows, Howard Fineman, Christy Harvey, Paul Krugman, Thomas Oliphant, Norman Ornstein, George Packer, Melanie Sloan, David Sirota, Bernie Sanders, and Lawrence O'Donnell Jr.