He previously served as the interim defensive coordinator for the Carolina Panthers and as an assistant coach for the Cleveland Browns, Arizona Cardinals and New York Giants.

Holcomb started his coaching career as a graduate assistant at Temple from 1995–96, helping with linebackers.

He spent six years from 1998–2003 at Bloomsburg University as linebackers coach and special teams coordinator.

[11] On January 16, 2019, Holcomb was hired as linebackers coach and run game coordinator by the Cleveland Browns.

[12] On January 19, 2020, Holcomb returned to the Carolina Panthers and was hired as their defensive run game coordinator.