He played college football at Notre Dame, and was selected by the New York Giants in the third round of the 2005 NFL draft, winning two Super Bowl titles with the team.

Tuck graduated from the University of Pennsylvania's Wharton School of Business with an MBA in 2018, and was employed by Goldman Sachs.

[3] His accolades include earning Alabama Class 4A Player of the Year as a senior in 2000,[4] as well as lettering in football at both linebacker and tight end.

Despite his limited playing time and one start against Rutgers, Tuck was named a third-team freshman All-American by The Sporting News.

[4] Nicknamed The Freak by his teammates for his raw athleticism,[9] Tuck holds several defensive records at Notre Dame.

In the run-up to the 2005 NFL draft, Tuck also recorded a wind-aided 4.56 in the 40-yard dash as well as a 380-pound bench press, 560-pound squat, and a 336-pound power clean.

[15] Tuck's rookie season in the NFL found him behind Pro Bowl defensive ends Michael Strahan and Osi Umenyiora on the New York Giants depth chart, reducing his role to special teams and the first backup at each defensive end position.

In total, Tuck played in 14 regular season games with one start and the NFC Wild Card Round.

[18] During his sophomore season in 2006, Tuck was limited to just six games due to an injury suffered on October 23, 2006, in a New York Giants Monday Night Football victory over the Dallas Cowboys.

[26] Due to the game's low score, opinions were heavily waged that Tuck was more deserving of the MVP award than quarterback Eli Manning.

[33] Tuck started his 2008 campaign in Michael Strahan-like fashion by sacking Washington Redskins quarterback Jason Campbell in the first play of the season opener.

[37] Tuck's stellar play in the 2008 season earned him a trip to the Pro Bowl as one of the NFC's starting defensive ends.

With the return of teammate Osi Umenyiora, Tuck hoped to see fewer double teams than he did during the end of the 2008 season.

Tuck recorded two tackles for a loss, 1.5 sacks, and a pass deflection, helping the Giants win by a score of 23–17.

[41] Tuck sustained an injured left shoulder when he was tripped by a Cowboys' lineman Flozell Adams in September, which affected his play for the rest of the 2009 season.

[43] Tuck continued to perform at a high level throughout the 2010 season and, along with Osi Umenyiora, proved why New York's pair of defensive ends were among the most feared in the league.

In Week 4, against Chicago, Tuck accounted for three of the defense's 10 total sacks, and had a forced fumble in a game the Giants won 17–3.

[46] The Giants finished with a 10–6 record and missed the playoffs after losses to the Eagles, who won the NFC East, as well as the eventual Super Bowl Champion Green Bay Packers.

[63] Tuck played in 15 games and recorded five sacks, 43 total tackles, one interception, three passes defended, and two forced fumbles in the 2014 season.

[70] In 1973, Jimmy Lee Tuck, Justin's father, built – by hand – the home that has housed his wife and eight children.

[69] During his youth, Tuck frequently attended Elam II Missionary Baptist Church in his native Kellyton, resulting in Justin becoming the congregation's youngest Sunday School instructor.

[72][69] After the Giants won Super Bowl XLII, Tuck achieved a new level of celebrity in his native Alabama.

He exchanged a game-worn football jersey for a game-used hockey stick with New York Rangers captain Jaromír Jágr.

Tuck and Giants teammate Michael Strahan teamed up with Nike to design their own exclusive pair of sneakers for ID studio in New York City.

[77][78] In May 2018, Tuck graduated from The Wharton School at the University of Pennsylvania with a Master of Business Administration in management.