[8] Iaquinta advanced into the TUF house by defeating Jon Tuck by unanimous decision after one round.

Iaquinta defeated Pichel via unanimous decision after two rounds and moved on to the finals against teammate Michael Chiesa.

Iaquinta lost to Chiesa by submission due to a rear naked choke early in the first round.

[15] Iaquinta faced Ryan Couture on August 31, 2013, at UFC 164, replacing an injured Quinn Mulhern.

[16] He won the bout via unanimous decision, after dominating the fight on the feet and negating all of Couture's takedown attempts.

Iaquinta was expected to face Anthony Njokuani on October 26, 2013, at UFC Fight Night 30, replacing an injured Paul Taylor.

[32] However, Green pulled out of the fight in mid-June, citing an undisclosed injury, and he was replaced by Gilbert Melendez.

[33] Subsequently, Melendez was removed from the card on July 6, after it was revealed that he tested positive for performance-enhancing drugs after his previous fight at UFC 188.

[36] However, Iaquinta announced on September 19 that he would not be taking the fight due to a contract dispute with the promotion.

[37] After two years away from the sport, Iaquinta returned to face Diego Sanchez on April 22, 2017, at UFC Fight Night 108.

[40] However, Iaquinta pulled out of the fight on October 31 due to being unsatisfied with his current contract, and he was replaced by Charles Oliveira.

[42] However, because of an injury to interim UFC Lightweight Champion Tony Ferguson and the state athletic commission's decision to pull replacement UFC Featherweight Champion Max Holloway over concerns over his weight cut, Iaquinta was scheduled as a replacement against Khabib Nurmagomedov in the five round main event.

[58] On February 23, 2020, Iaquinta faced Mike Perry at Chael Sonnen's Submission Underground 11 event.

He started the process of acquiring a license after a contract dispute for his fight against Thiago Alves at UFC 205.