The western terminus of the highway was at an intersection with U.S. Route 31 (US 31) in Bay Minette.

The eastern terminus of the highway was at the Florida state line, west of Muscogee, where the roadway continues as Escambia County Road 184 (CR 184).

It curved southeast towards Gateswood, an unincorporated community.

Gateswood was where SR 112 met Baldwin County Route 64 (CR 64).

[2] In July 2004, a road exchange occurred: SR 181 extended south from US 90 to US 98 replacing part of Baldwin County route 27, and SR 112 was decommissioned and replaced by Baldwin County route 112.