The eastern terminus of the highway is at an intersection with SR 51 north of Enterprise.

It heads northwest on two-lane undivided McKinnon Street.

In the center of New Brockton, the highway turns northeast onto North John Street and continues past more residences.

Upon leaving New Brockton, SR 122 heads into a mix of farmland and woodland as an unnamed road.

The highway turns more to the east before it reaches its eastern terminus, an intersection with SR 51.