The western terminus of the highway is at an intersection with SR 65 in Swaim, an unincorporated community.

It travels to the south-southeast and almost immediately intersects the southern terminus of Jackson County Route 9 (CR 9).

After an intersection with Jackson CR 138, the highway curves to the northeast and crosses over Guess Creek.

It curves to the east-southeast and intersects the northern terminus of Jackson CR 544 on the northwestern edge of Sanders Cemetery.

Approximately 1,500 feet (460 m) later, SR 146 intersects the eastern terminus of Jackson CR 545.