SR 185 begins at its intersection with US 31 south of Greenville.

[2] From this point, the route continues in a northerly track where it intersects SR 10 just west of the Greenville central business district.

[4] SR 185 then reorients in an easterly direction at Fort Deposit and continues its course where it again intersects I-65 (Exit 142) prior to reaching its northern terminus at US 31.

The truck route allows large vehicles to bypass the roundabout at the county courthouse downtown.

The entire route is in Greenville, Butler County.