SR 295 begins at its intersection with US 43 just south of Grove Hill.

[2] The route progresses in a northerly direction past the Grove Hill Memorial Hospital just prior to reaching its intersection with US 84.

[3] SR 295 continues in its northerly track through the central business district of Grove Hill prior to intersecting US 43 at its northern terminus north of the town.

[4] The entire route of SR 295 is the former alignment of US 43 prior to the 4-Lane bypass being built to the west.

[citation needed] The entire route is in Grove Hill, Clarke County.