The southern terminus of the highway is at an interchange with Interstate 85 (I-85) at Franklin in Macon County.

The northern terminus of the highway is at an intersection with SR 281 east of Cheaha State Park in southern Cleburne County.

A few miles south of Lineville is a two-mile concurrency with Alabama State Route 77.

It then winds its way south through Jacksons' Gap and reaches Dadeville, the location of a mile-long concurrency with U.S. Route 280.

It makes a left turn onto the right-of-way of County Road 36, which carries it to its southern terminus at Interstate 85.