The southern terminus of the highway is at an intersection with U.S. Route 231 (US 231) south of Madrid.

After a crossing of Big Creek, it curves to the north-northwest and enters Rehobeth for a very brief distance.

After another short distance out of the city limits, the highway intersects SR 109 on the southern edge of the town.

[3] The highway intersects the western terminus of County Route 10 (CR 10, Mance Newton Road) just before crossing over Harrison Mill Creek.

The highway then intersects the eastern terminus of CR 554 (Hawkins Hill Road).

[4] SR 605 was created in December 2012 through a road swap between Houston County and the Alabama Department of Transportation (ALDOT).