The southern terminus of the highway is at an intersection with SR 14 at Claud, an unincorporated community in Elmore County.

The northern terminus of the highway is at an intersection with SR 9 south of Millerville, an unincorporated community in southeastern Clay County.

The highway crosses over Lake Martin as it travels from Elmore County into Tallapoosa County, passing the entrance to Wind Creek State Park along the lake.

At Alexander City, SR 63 intersects U.S. Route 280 (US 280), a major highway heading southeast from Birmingham.

SR 63 continues northward through Alexander City into rural Tallapoosa County, then enters the southern tip of Clay County before reaching its northern terminus.