Other cities and towns along the highway include Center Point, Pinson, Oneonta, Albertville, Geraldine, and Rainsville.

SR 75 begins at an interchange with I-59 and US 11 at the intersection of Parkway East, Roebuck Drive, and Gadsden Road in eastern Birmingham.

Turning onto SR 151's right of way, the route continues as a four-lane divided highway into Blount; although some short portions are undivided.

Traversing its way into a mountain valley, the route passes through Allgood and Oneonta before losing two lanes (one in each direction) and becoming a traditional two-lane rural road.

Continuing onward up to the state line, the route serves several crossroads communities, such as Henagar and Ider.