The eastern terminus of the route is at its junction with SR 68 approximately eight miles northeast of Boaz in southwestern DeKalb County.

From its western origin at Douglas in southeastern Marshall County, the route travels eastwardly as it leads towards Boaz.

At Boaz, the route turns northeastwardly, crossing US 431 and leading into DeKalb County.

The eastern terminus of the route is at Kilpatrick, an unincorporated community near the border of DeKalb and Marshall Counties.

[2] SR 168 passes several outlet malls near downtown Boaz.