The Spurs played in the Alamodome for a decade, then became disenchanted with the facility and convinced Bexar County to construct a new arena for them, now called the Frost Bank Center.

The footprints for the 28 unbuilt luxury suites were open floor space just behind the club level seats that surround the south end of the facility.

As the years passed, Spurs management and fans grew increasingly dissatisfied with its poor sight lines and cavernous feel.

Moving the Spurs out of the Alamodome opened up more contiguous dates allowing the facility to schedule more events, though it has yet to host a Super Bowl.

Army has elected to play its "home" game at the Alamodome in order to increase the program's exposure around the nation, as it competes as an independent.

The Alamodome hosted the Conference USA Football Championship Game in 2021 and 2022 with UTSA defeating Western Kentucky 49-41 and North Texas 48–27.

In 2005, the NFL announced that the Alamodome would host three of the New Orleans Saints' regular season "home" games due to the damage caused to the Louisiana Superdome by Hurricane Katrina.

Overall, the Saints averaged 62,665 fans in the 64,000-seat Alamodome for the three games held there, a solid showing despite the short notice to sell tickets due to the hurricane.

Cowboys owner Jerry Jones has acknowledged his support for the city's efforts to become home to an NFL franchise even though public opinion is that he would never let go of his team's presence in the San Antonio market.

[27] The Raiders decided against moving to San Antonio, first proposing unsuccessfully to return to its previous home in Los Angeles, then ultimately receiving permission to relocate to Las Vegas in 2020 by constructing Allegiant Stadium.

The stadium was attractive to the Canadian Football League (which made an ill-fated attempt to expand to the U.S. between 1993 and 1995) since it was one of the rare American facilities that could fully accommodate the CFL's larger playing field and, having just recently opened, was one of the most modern facilities in a league where the majority of its teams were playing in decades-old or poorly fit stadiums.

In the first CFL playoff game ever played between two U.S.-based franchises, the Texans defeated the Birmingham Barracudas 52–9 at the Alamodome on November 5, in front of 13,031 fans.

The Talons, who relocated from Tulsa, Oklahoma, in 2011, won the Central Division title in 2012 with a 14–4 record but were upset in the first round of the playoffs by Utah.

In October 2020, Fox Sports 1 reached a multi-year agreement to televise The Spring League along with the option to acquire a minority stake in TSL.

The league began its fall season October 27 with six teams competing in a 12-game format over four weeks in a bubble environment, based out of the Alamodome.

After experiencing problem with the COVID-19 virus at the Dome, however, the final week's games were rescheduled for a high school field in San Antonio, then cancelled.

The TSL championship game, also originally scheduled to be played at the Alamodome, was held at Camping World Stadium in Orlando on December 15, 2020.

The Rangers took on the San Diego Padres in 2013, the Houston Astros in 2014, the Los Angeles Dodgers in 2015, the Kansas City Royals in 2016,[32] and the Cleveland Indians in 2017.

The Mexican national soccer team first played in the Alamodome on June 19, 2004, in a FIFA World Cup qualifier, defeating Dominica 10–0 in front of 37,642 fans.

[40] The match was marred by Mexico's displeasure with the temporary grass field laid on the Alamodome floor, which was described as "uneven" and "full of patches".

[46] A new expansion bid plans to use Toyota Field, a soccer-specific stadium used by San Antonio FC, for the MLS team instead of the Alamodome.

[50] It has also hosted concerts to artists such as Shakira, The Rolling Stones, U2, Prince, Elton John, Tina Turner, Rod Stewart, AC/DC, George Strait, Britney Spears, Guns N' Roses, *NSYNC, Backstreet Boys, Janet Jackson, Metallica, Pink Floyd, Alice Cooper, Def Leppard, Mötley Crüe, Scorpions, Rammstein and many more.

This event marks the first time in the DCI season all the World Class drum corps compete against each other on the same field, and therefore get scored by the same judges.

The first occurrence took place on January 19, 1997, in front of a packed crowd of just over 60,000 and saw San Antonio native Shawn Michaels defeat Sycho Sid for the WWF World Heavyweight Championship in the main event.

Roman Reigns defeated Kevin Owens in the main event to retain the Undisputed WWE Universal Championship and was betrayed by his Bloodline member Sami Zayn afterwards.

On April 19, 2007, the San Antonio City Council unanimously approved an additional $8.3 million to fund renovations and enhancements to the facility.

In 2024, the city estimated a renovated Alamodome, anchoring a new sports park in downtown San Antonio, could combine to cost $3-4 billion.

[60] In 2011, the Alamodome introduced a new configuration branded as the Illusions Theater, wherein the north end of the stadium can be partitioned into a smaller, pop-up auditorium setting with a ceiling, carpeting, and stage.

The configuration was designed to host mid-sized events (which, prior to its closure and renovation, were primarily held at the San Antonio Municipal Auditorium), including concerts, conventions, and graduation ceremonies.

[11] In 2016, the San Antonio City Council approved $50 million worth of upgrades to modernize the facilities to keep it competitive for NCAA events.