The arena was most notably used as the practice facility for the NBA's New Orleans Pelicans (formerly Hornets) from 2002 to 2013.

The Alario Center also hosts many annual sports events including AAU Boys Basketball tournaments, boxing matches, cheerleading/dance competitions, wrestling, professional wrestling, gymnastics meets and volleyball tournaments.

There are also many non-sports events that are annually held at the Alario Center including the FIRST Robotics Competition Bayou Regional, the Governor's West Bank Luncheon, concerts, college graduation ceremonies and numerous sales & expos.

[2][3] On April 4, 2014, the venue hosted Supercard of Honor VIII, a professional wrestling event promoted by national wrestling promotion Ring of Honor (ROH).

The Bayou Segnette Sports complex, which the Alario Center is part of also includes Segnette Field, a baseball stadium that is the home of the Loyola University New Orleans' Wolfpack baseball program.