The club was a powerhouse during the 1940s as a Class A farm team of the Pittsburgh Pirates, posting winning records between 1942 and 1948, making the Eastern League playoffs six times, leading in attendance five times, and taking the 1945 EL championship.
Among the Pittsburgh farmhands who played for the club was Hall of Famer Ralph Kiner, in 1941–42.
The last-place 1959 Senators — the latest in a succession of poor clubs — drew only 45,000 fans for the season and Albany was dropped from the Eastern League when it contracted from eight to six teams for 1960.
Professional baseball and the EL would not return to New York's state capital until 1983, when the West Haven A's moved to the area as the Albany-Colonie A's (now the Richmond Flying Squirrels).
The current pro baseball team in the Albany area is the Tri-City ValleyCats of the Frontier League.