At the beginning of the American Civil War, he moved to Graham, Missouri, where he taught school.

While camped in Lafayette County, Missouri, he met his future wife Mattie McFadden.

He was to actively pursue legislation to establish a Normal school in Maryville that eventually would result in Northwest Missouri State University locating in the town.

As Lieutenant Governor, Morehouse assumed office on December 28, 1887, upon the death of John S. Marmaduke.

After rupturing a blood vessel in his brain from an accident while herding cattle, Morehouse became delirious and didn't know what he was doing.