On February 19, 1910, a schoolhouse bond of $8,000 (for constructing and equipping a public free school building of wood material) was passed by the citizens.

[11] On June 18, 1932, District 29 residents voted 123-44 for a $40,000 bond to consolidate the four schoolhouses for white students (Aldine, Brubaker, Higgs and Westfield) into one new centralized school.

[15] The new, as yet unnamed school opened in February 1933 at the intersection of Aldine-Bender Road and Aldine Westfield and immediately was filled to capacity.

On November 24, 1954, the main building of Aldine High School was destroyed by a six-alarm fire.

[23] A new high school campus was built in 1956 at 11101 Airline Drive at West Road on the site of the former Gulf Coast Airport.

[24] As of January 1, 1956 Aldine ISD still included parts of Oak Forest, the area north of Brickhouse Gully and West of White Oak Bayou,[25] Katherine Smith Elementary was part of Aldine ISD.

On September 17, 1958, the county school board ruled for the residents and said AISD had to cede 3 square miles of Oak Forest and Langwood to HISD.

[26] In 1964, George Franklin Sampson attempted to enroll his children at Aldine High School.

[28] As a result, the district was placed under a federal court order to redraw attendance zones so that every school in 1978 would have less than 30% black enrollment.

[29][30] In 2023 the Aldine ISD Board of Trustees voted unanimously to use the power of eminent domain to seize the home of Travis Upchurch, 79 years old and lifelong Aldine resident, to expand their high school football stadium parking lot.

The property has been in Upchurch's family since 1916 and has housed five generations, including his great grandfather and his children.

After months of his family and the community fighting the district dropped their pursuit, conveninently right before elections where a majority of the board's seats were being contested.

[31] Aldine ISD received the Broad Prize for Urban Education in 2009 and was a finalist for the award in 2004, 2005, and 2008.

[32] The district received a Magna Award in 1999 from the American School Board Journal for its "Benchmark Targets for Academic Achievement" program.

91.6% of students were economically disadvantaged, 39.0% were English Language Learners, and 9.0% received Special Education Services.

Sonny Donaldson Administration Building, a two-story facility in unincorporated Harris County, Texas, across from Nimitz High School.

[49] The school district acquired the facility in spring 2015 from Baker Hughes and opened it on March 21, 2016, with the dedication ceremony on April 19 of that year.