Nimitz first opened its doors in the fall of 1978, relieving both Aldine and MacArthur High School.

[5] The student demographics at Nimitz High School for the 2023-2024 school year was: 86% of students were Economically Disadvantaged, 6% were English Language Learners [6] While the school has a Houston address, it serves students in portions of unincorporated Harris County, Bordersville, the AISD portion of Humble (including communities such as Inverness Forest, Woodcreek, Memorial Hills, Kenswick, Foxwood, and Deerbrook Estates), and a small portion of East Aldine (areas north of Aldine Bender).

[7][8] Due to the tremendous growth in the areas serving AISD, the district opened Benjamin O. Davis High School in the Fall of 2012.

Communities in the Greenspoint area of the Nimitz attendance zone were directly affected by the school's opening.

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