Established in 1968 in Milwaukee, Wi, Aldrichimica Acta publishes reviews in the field of synthetic organic chemistry, with each issue focusing on a special topic.

[2] In 1968, Aldrich Chemical Company published Volume 1, Number 1 edition of Aldrichimica Acta.

The Acta both replaced Klarindex Sheets as a scientific journal meant specifically to keep chemists informed, as well as complemented the company's world-famous annual catalog, the Aldrich Handbook of Fine Chemicals.

Despite seeing mergers with Sigma Chemical Company of St. Louis in 1975 and Merck KGaA in 2015, the journal has retained its name.

Each edition of Aldrichimica Acta contains a unique piece of art on the cover, as well a description on the inside to give the reader more information.