Agresti is best known in the United States for his feature Valentín, the story of a young boy who dreams of becoming an astronaut while attempting to better the bewildering world around him.

El Viento se llevó lo qué tells the story of a Buenos Aires cab driver who goes to an isolated village where the only contact with the outside world is through movies.

Longing to broaden his horizons, he immigrated to the Netherlands, where he exhibited El Hombre que ganó la razón at the International Film Festival of Rotterdam in 1986.

Other popular Agresti films include La cruz ("The Cross"), the story about a film critic whose job loss precipitates a family crisis; the popular comedy A Night With Sabrina Love, the tale of a teenager who unexpectedly wins an evening with a famous porn star in a television contest; City Life, Luba, Figaro Stories, Everybody Wants to Help Ernest, A Lonely Race, Modern Crimes, and El Acto en cuestión ("The Act in Question"), which won more than a dozen international film awards.

[2] In 2016 he released Mecánica popular, an Argentine comedy-drama film he wrote and directed, starring Alejandro Awada and Patricio Contreras.