He achieved popularity in Latin America thanks to The Alejandro Hernández Show, a comedy web series which satirizes Venezuelan and Hispanic culture.

[5] Before creating the YouTube channel, Hernández made several short films in both English and Spanish, such as "Conditioned", a comedy-drama about a nerd who criticizes society and stereotypes.

[13] Mario Silva, host of La Hojilla, an opinion program that airs on the government channel Venezolana de Televisión, harshly criticized Hernández, saying that he looked "apparently innocent" and labeled him "dangerous" and a bad influence to the Venezuelan youth.

[citation needed] "Tamos Ready", a parody song mocking the Reggaeton genre was released on 28 December 2010 along with episode 20.

The 1-minute song became a local hit, reaching more than 20,000 digital downloads and positioning both "Alejandro Hernández" and "Tamos Ready" at Twitter's worldwide trending topics.

[14] Hernández generally composes music with mainstream appeal, such as "Take It to the Floor", which was featured on episode 29 as part of a sketch.

[18] Hernández came out as gay in early 2015 through an open letter on his blog,[19] causing diverse reactions in the Venezuelan media and becoming the first celebrity to publicly state their sexuality in the country.