He manages the Santo Domingo Group, his family's conglomerate, with his net worth estimated by Forbes to be US$2.6 billion as of May 2023.

Santo Domingo also owns a minority stake in the Washington Commanders of the National Football League (NFL).

He is also the managing director of Quadrant Capital Advisors,[2][4] member of the AB InBev finance committee,[4] chairman of Bavaria Brewery,[4] director of the Colombian network Caracol Televisión and newspaper El Espectador,[4] chair of the Wildlife Conservation Society,[4] and board member of the Metropolitan Museum of Art,[5] DKMS, WNET, Mount Sinai Health System, the British Museum,[6] and the Barefoot Foundation.

During the years he has been seen with several famous socialite girlfriends, which have included heiress Amanda Hearst, editor Karen Larrain and models Eugenia Silva and Julie Henderson.

[10] In July 2015, he announced an engagement to Lady Charlotte Anne Wellesley, daughter of Charles Wellesley, 9th Duke of Wellington and Princess Antonia of Prussia, great-great-granddaughter of the late German emperor Wilhelm II.