Eugenia Silva grew up in a family of jurists; Antonio Hernández Mancha is her uncle.

She graduated in Law from Colegio Universitario Cardenal Cisneros, which is affiliated with Madrid's Complutense University.

Her career took off when she moved to New York City, where she was chosen to be the face of Oscar de la Renta.

Throughout her career, she has appeared in many advertisement campaigns, including Armani, Loewe, Oscar de la Renta, Pantene, Dolce & Gabbana, Carrera y Carrera, Escada, Garnier, Intimissimi, Magnum, Max Factor, Tiffany & Co., and Chopard.

She is an ambassador for Fundación Plan International,[6] an NGO that works to improve the lives of children in 49 countries in Africa, Latin America and Asia.