A striker, he played for Argentina between 1929 and 1941, and competed at the inaugural 1930 FIFA World Cup.

In 1931 he scored 31 goals for the team but was beaten to the golden boot by teammate Alberto Zozaya's 33.

During this time he took the Italian citizenship (as oriundo) and played for the Italy national team.

After retirement he became a manager, coaching many club teams including Club América in Mexico, and Valencia CF Español and Deportivo de La Coruña in Spain, Belenenses[4] Sporting CP and FC Porto in Portugal and Universidad de Chile.

Scopelli was the Sporting CP manager in the inaugural game of European Cup on 4 September 1955 against FK Partizan Belgrade.